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Cyano B12 in particular should be avoided, especially in patients with pernicious anemia and/or with high homocysteine

PLoS Pathogens 10:e1003902 Boradia V, Frando A, Grundner C (2022) The Mycobacterium tuberculosis PE15/PPE20 complex transports calcium across the outer membrane

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The study found that serum B12 levels were comparable, and in some cases higher, among those using the sublingual supplement (1)

[99] A person with cobalamin C disease, a rare autosomal, recessive, inheritance disease which results in combined methylmalonic aciduria and homocystinuria), [100] can be treated with intravenous or intramuscular hydroxocobalamin