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Exp Dermatol 23(3):178183 Yoshihisa Y, Andoh T, Matsunaga K, Rehman MU, Maoka T, Shimizu T (2016) Efficacy of astaxanthin for the treatment of atopic dermatitis in a murine model

UCP1 expression is not sufficient proof of thermogenesis

While these differences are generally small for weekly injections, maintaining consistent site selection within each escalation phase can reduce one variable that might otherwise confuse your assessment of dose response

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Neither is universally "better" they do different things