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The hosts innate intestinal defense system consists of a protective mucus layer and a specialized epithelial barrier, sustained by diverse, functionally distinct cell types
All experiments were performed at 25 C in a buffer solution containing 20 mM HEPES (pH 7.0), 150 mM NaCl, and 1 mM DTT
With age, mGSH declines selectively, contributing to the mitochondrial dysfunction that underpins the "mitochondrial theory of aging." Restoring systemic GSH levels supports mGSH replenishment, with downstream effects on cellular energy production and biological aging rate
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