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The SEMALEAN study, published in 2025, tracked 115 semaglutide patients over 12 months using DEXA scans and found that while total lean mass initially declined, it stabilized by month 12 while fat mass continued dropping throughout

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Due to this rapid degradation, endogenous GLP-1 secreted from the gut must exert its biological effects immediately upon release

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Retatrutide's unique mechanism positions it favorably against emerging competitors and established therapies

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Small changes kept long term beat big fixes that fade

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