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The egg maturation process, ovulation, and fertilization all require substantial energy supply

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Although the contribution of dietary methionine excess (which increases folate, vitamin B 6 , and vitamin B 12 requirements) has not been clinically assessed, folate deficiency (associated or not with the thermolabile MTHFR mutation) and vitamin B 6 deficiency (associated or not with heterozygosity for CBS defects) could largely account for this increased risk of hyperhomocysteinemia-related cardiovascular disease

FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis

2b), which restricts the conformational flexibility of arbutin in this binding mode, thereby limiting opportunities for additional interactions