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Similarly, exenatide ameliorated the inflammatory response in human RA FLSs by decreasing the oxidative stress capacity of FLSs and down-regulating the expression of IL-1 and IL-6, while suppressing the initiation of p38/MAPK and NF-B signal transduction pathways [240]

They enhance glucose-dependent insulin secretion, suppress glucagon release, and slow gastric emptying, while supporting the preservation of pancreatic beta-cell function

Spanswick D et al

Semaglutide's mechanism of slowing gastric emptying and its common gastrointestinal side effectsincluding nausea, vomiting, diarrhea, and abdominal painoverlap significantly with UC symptoms

In 1961 he completed a BSc at Durham University