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doi: 10.1016/j.ncrna.2024.05.007 25 ZhangMChenXZhangY

287 Surgical menopause occurs in reproductive-aged women who have had both ovaries surgically removed

Glutathione is the most abundant intracellular thiol (i.e., a compound containing a sulfhydryl [SH] group) and low molecular weight tripeptide found in living cells.* The antioxidant functions of Glutathione Reduced include recycling vitamins E and C and serving as an antioxidant in all types of tissues.*

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Here, we used phage-assisted evolution to reprogram botulinum neurotoxin serotype X proteases to cleave and activate procaspase-1 and gasdermin D, key effectors of inflammatory cell death