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Because MOTS-c is a mitochondrial peptide not normally present in the extracellular space at pharmacologic concentrations, its subcutaneous bioavailability and degradation kinetics in humans remain poorly characterized

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Results Body weight, fat mass, and cecal mass As expected, obese mice (maintained on an HFD followed by WD) had significantly higher body weights than mice continuously maintained on LD

Moreover, those who combine diet with intense physical activity or high-output cardio may experience increased fatigue if B12 levels are not optimal

This property is essential for the compound to exert its metabolic effects