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NMDA mediates disruption of blood-brain barrier permeability via Rho/ROCK signaling pathway
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The model uses patient-level simulation to capture disease complexity and brings novel approaches to long-standing modeling challenges in T2D, including use of model averaging to estimate the risk of specific complications (where the average of multiple risk equations derived from different populations is applied, with higher weight given to equations derived in populations that more closely match the characteristics of each sampled patient) and modeling the progression of CKD based on mapping of eGFR to KDIGO stages 15, with kidney failure defined as KDIGO stage 5
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