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Here's why B12 doesn't directly cause weight gain: Water-Soluble Nature : Vitamin B12 is a water-soluble vitamin

Growth hormone fragments have shown potential in stimulating chondrocytes (cartilage-producing cells) and promoting collagen synthesis, which may benefit individuals with osteoarthritis or joint degeneration

Because the two pathways dont compete for the same receptors, researchers have noted this as a mechanistically distinct pairing worth studying one acting directly on adipocytes, the other acting systemically through growth hormone signaling