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At 24 weeks, liver fat reductions were significant: 42.9% (1 mg), 57.0% (4 mg), 81.4% (8 mg), and 82.4% (12 mg), compared to a 0.3% increase in the placebo group
These hormonal shifts can overpower the appetite-suppressing effects of low-dose tirzepatide
therefore, SSRIs in general and fluoxetine in particular should be used with caution (Sjaarda et al., 2020)
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