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Enzymatic antioxidant defense cannot rely solely on SOD, because that would result in markedly increased tissue damage due to high accumulated levels of intracellular H 2 O 2 , the substrate for production of OH via the Fenton reaction
This hypothesis was supported in a recent study with a 20-year follow-up, which found chronic low dose exposure to POPs predicted excess adiposity, dyslipidemia, and insulin resistance among participants without diabetes, in a U-shaped fashion (characteristic of endocrine disruption)
Most of IGF1 is bound to one of 6 binding proteins (IGF-BP)
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From the lab to patients: a systematic review and meta-analysis of mesenchymal stem cell therapy for stroke
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