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Multi-omics studies revealed that SARS-CoV-2 infection provokes significant changes in numerous metabolites including those impacting on virus propagation (one-carbon metabolism) and GSH synthesis (amino acids glutamic acid, cysteine and glycine) that could be used as early prognosis biomarkers in COVID-19 at diagnose to predict severe COVID-19 and LONG COVID (Doan et al., 2021
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We have also showed that other markers of DNA damage/cell cycle (p21, p53, p57 and phospho-p57, GADD45, 8-OHdG), apoptotic (BCL-2, CASP-2, CASP-9) and anti-oxidant pathways (GP-1, SOD-1, HO-1, p38 stress kinase), that are not specifically associated with hair follicle pigmentation, have distinct expression patterns and colocalise to parts of the hair follicle such as the IRS, ORS, DP and cortex
This observation further strengthened the notion that additional binding free energy could be gained not only by forming meaningful interactions with the doorstop pocket but also by liberating the trapped waters
