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While Semaglutide targets the GLP-1 hormone receptor, Tirzepatide targets both GLP-1 and GIP hormone receptors

Presented for research literature review only Corley M et al

Sunehag AL, Treuth MS, Toffolo G et al (2001) Glucose production, gluconeogenesis, and insulin sensitivity in children and adolescents: an evaluation of their reproducibility

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Among successful interventions, once-weekly semaglutide demonstrated the greatest efficacy, with patients achieving a standardized mean difference (SMD) of -2.101 (back-transformed to a mean difference of about -15.76 kg) versus control