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Pickart L, Margolina A

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Redox signaling in rheumatoid arthritis and the preventive role of polyphenols

Additionally, two-year safety data from the STEP 5 trial shows that while gastrointestinal events occurred in 82% of participants at some point during the study, most of these events were concentrated in the initial 6 months, with frequency and severity declining markedly in long-term treatment

Graphical Abstract Similar content being viewed by others Introduction Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, accounting for approximately 17.9 million deaths annually, representing around 32% of all global deaths [1]