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Comparing With Fed-State Administration When taken with foodespecially high-fat mealsstomach enzymes can accelerate peptide degradation, potentially lowering the effective dose
FASEB J
Optimised Absorption: Even with malabsorption, theres a small amount of B12 that can be absorbed passively at very high oral doses
Reduced effectiveness: If your typical dose seems less effective than previous weeks from the same vial, potency may have decreased
Oxidation of sensitive residues, altering structure and function
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