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The presence of gestational diabetes and hypertensive disorders increases the risk of preterm birth, which was 34 % higher among exposed women
The bidirectional nature of the MGBA further implies that not only can the brain influence gut health, but gut-targeted interventions may offer tangible neuroprotective benefits
However, previous studies have found that DPP-4 can be regulated by inflammatory factors such as signal transducer and activator of transcription 1 (STAT1), hepatocyte nuclear factor-1 (HNF-1), interleukin-12 (IL-12), and tumor necrosis factor- (TNF-) [33,34,35]
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![Inhibitory effect of methotrexate on NADPH-dependent oxidoreductases [6]](https://www.researchgate.net/publication/272373900/figure/tbl1/AS:669629584269315@1536663542176/nhibitory-effect-of-methotrexate-on-NADPH-dependent-oxidoreductases-6.png)
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