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What to Expect for Skin Quality on Semaglutide Injection Patients beginning compounded semaglutide injection therapy at PlexusDx typically notice initial skin changes within 8-12 weeks as fat loss begins and inflammation markers decrease

Published online April 23, 2013

Results, published in September 2025 in The New England Journal of Medicine , show that high-dose oral semaglutide tablets (25 mg) led to an average weight loss of about 1417% over a little more than a year , along with additional benefits like lower blood pressure and reduced inflammation

Tirzepatide itself has become the most talked-about weight loss medication since semaglutide changed the conversation around obesity treatment