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Presented for research literature review only Arans C et al
The published data regarding agonist-induced internalization of GIPR are just as conflicting as, if not more so than, that for GLP-1R
Safety Profile The most common adverse events documented across retatrutide results data were gastrointestinal in nature, with incidence increasing at higher doses: Nausea: 6-31% (dose-dependent), primarily during escalation periods Diarrhea: 6-25%, generally mild to moderate Vomiting: 0-16%, occurring mainly in the first weeks of each dose increase Decreased appetite: 3-19%, which contributed to the weight reduction effect Constipation: 3-12%, consistent with GLP-1 receptor-mediated gastric slowing Serious adverse events were rare across all cohorts
Activities that engage the core and promote general movement are beneficial
This tool provides an additional way for employees to tap HSAs for GLP-1 and other healthcare costs as eligibility broadens
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