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The extended titration schedule helps minimize gastrointestinal adverse effects such as nausea, vomiting, and diarrhea, which are the most common reasons for treatment discontinuation

Tirzepatide (Mounjaro, Zepbound) Tirzepatide is a dual GIP/GLP-1 receptor agonist, meaning it targets two incretin receptors instead of one

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes and, more recently, for chronic weight management in adults with obesity or overweight with weight-related comorbidities

[118] Dose timing may influence both efficacy and adverse effects, with morning administration generally preferred to mimic natural cortisol circadian rhythms