Lastly, semaglutide downregulated several known regulators of pathologic hypertrophy (including Nppa, Ankrd23, Myh7, Gja5, Calm1), providing molecular insight into the antihypertrophic action of these drugs in HFpEF ( Figure 1C )
Injection site reactions are the most commonly reported dermatological effects with subcutaneous semaglutide (Ozempic and Wegovy) and typically present as redness, itching, bruising, or mild swelling at the site of administration
How it evolved over time, and as new theories pop up, that opens up new areas of research and potential new therapeutics
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[2] [3] Whilst Ozempic has gained attention for its weight loss effectswhich occur as a secondary benefit of its mechanismit is important to understand that in the UK, it is not licensed as a weight loss medication