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Most importantly, numerous other neuroprotective and neurotrophic growth factors like BDNF-analogs and LM11A-31 are currently being studied for their cognitive and therapeutic benefits, especially their ability to preserve and promote neural networks and neuron health, particularly in the setting of neurodegenerative diseases like Alzheimer's disease, FrontoTemporal Dementia (FTD), Parkinson's Disease (PD), and Lewy-Body Disease, as well as ischemic or traumatic neural injury (68a) (68b) (68c) (68d)
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A separate class-level subgroup analysis excluding trials with study populations least comparable to SURPASS-CVOT, specifically ELIXA, which enrolled patients with recent acute coronary syndrome (within 180 days of medication initiation), and FLOW, a dedicated CKD outcomes trial
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