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Intragastric and oral administration give detectable plasma levels for several hours in rodent studies, supported by the proline-rich sequence resisting cleavage by gastric proteases
Advances in Peptide Research, 22 (3), 121-134
doi:10.1016/j.mcn.2021.103669
Receptor Interaction: The peptide modulates beta-3 adrenergic receptors on adipocyte membranes, increasing receptor expression and sensitivity
Its FDA-approved for HIV patients, but can be prescribed off-label to reduce visceral fat, raise low IGF-1 levels, or support recovery and metabolic health, typically after foundational hormones like testosterone are optimized
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