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Although DLTs did not occur in all patients, most patients had low-grade gastrointestinal disease
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Limitations of current therapeutic strategies Current clinical management of RIRI primarily relies on antioxidant agentssuch as N-acetylcysteine and vitamins E/Canti-inflammatory drugs including non-steroidal anti-inflammatory agents (NSAIDs), and nephroprotective compounds like amino acids and indomethacin, often supplemented by supportive measures such as fluid resuscitation and extracorporeal blood purification
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