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It was first characterized by Sikiric and colleagues at the University of Zagreb, who were investigating why the stomach lining tolerates such a harsh environment
Anelli et al
Degnan, P
These molecules, in excess, can cause an imbalance in our body, leading to a state of oxidative stress
Additionally, PBD-DNA adducts minimally distort DNA, allowing for evasion of DNA damage repair processes and decreasing the risk of emergent drug resistance 48
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