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The combination of PBD and an antibody against ApoD demonstrated a senolytic readout by eliminating senescent fibroblasts without any effect on young cells

This cascade crosstalks with the ErbB2, PI3K/Akt, and MAPK pathways, thereby circumventing trastuzumab-mediated HER2 inhibition and promoting drug resistance

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placebo n = 6) received at least one dose and were included in the safety analysis