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Accompanied by the downregulation of GPX4, lipid metabolic enzyme dysfunction further drives the disruption of lipid peroxidation and iron imbalance during the middle and late stages of renal fibrosis, which is consistent with previous report [13, 14, 36, 37]

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Importantly, these expanded HBs retained bipotency, co-expressing both hepatic and early cholangiocyte markers [1]

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