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In fact, several recent studies that have conducted genome wide searches for common genetic defects across large samples of ASD children have only identified rare de novo mutations, thereby pointing to acquired mutations and/or mutations secondary to errors in DNA maintenance rather than inherited genetic syndromes (11, 12)

doi:10.7326/0003-4819-142-6-200503150-00006 22

That tradeoff only makes sense when a clinician sees a clear reason in your case

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