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In our initial statistical analysis plan, these covariates were systematically forced into the models: age, sex, BMI and HbA1c, diabetes mellitus duration, ACE inhibitors (ACEI) or angiotensin receptor blockers (ARB) intake, SARS-CoV-2 vaccination data, comorbidities, and anti-diabetic drugs

This shift raises important questions about safety, tolerability, and long-term outcomes

Mol Reprod Dev

Specifically, the control group and model group were distinctly separated along the PC1 axis, indicating that the model induction caused significant metabolic perturbations

For semaglutide, discontinuation is required at least 2 months before a planned pregnancy as a result of its long half-life