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For people from certain ethnic backgrounds, including South Asian, Chinese, Black African or African-Caribbean, the BMI thresholds are lower (typically 27.5 kg/m or greater, or 25 kg/m with comorbidities)

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Glutathione can also cause changes to gene expression, DNA and protein synthesis, cell division and growth, and programmed cell death (apoptosis)

For someone losing 23% weekly with rising ALT or persistent afternoon energy crashes, it's mechanistically justified intervention