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Shah S, Henry A, Roselli C, Lin H, Sveinbjornsson G, Fatemifar G, et al

Yes, age can be a factor

A 45-degree angle reduces effective penetration depth and is recommended when you can only grasp about 1 inch of tissue, when using longer needles, or when injecting in sites with thinner subcutaneous fat

That doesnt mean everyone taking the higher dose will experience dysesthesia, but its worth asking about before moving up, especially if your current dose is already working or if youve had unusual skin sensations on a GLP-1 medication before

4.8 Electrolytes (Potassium, Sodium) Physiological Role Electrolytes regulate: Fluid balance Cardiac conduction Neuromuscular function Why GLP-1 Therapy May Influence Electrolytes Electrolyte imbalance may occur secondary to: Persistent vomiting Diarrhoea Reduced fluid intake Rapid weight loss This is most relevant during dose escalation or in patients with ongoing GI symptoms