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Gallbladder disease , including gallstones, has been reported with GLP-1 receptor agonists
However, serious adverse effects can occur, including pancreatitis (severe persistent abdominal pain), gallbladder disease, and acute kidney injury (typically related to dehydration from gastrointestinal symptoms)
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For more frequent protocols, the loss is proportionally higher
While the medication does not directly cause muscle weakness through a neuromuscular mechanism, the combination of fatigue, gastrointestinal symptoms, rapid weight loss, and dietary changes associated with semaglutide therapy creates a clinical context where weakness can reasonably occur as a secondary phenomenon
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