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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

This scoring system allowed for semi-quantitative evaluation of cartilage integrity based on macroscopic features such as softening, fibrillation, erosion, ulceration, and complete cartilage loss [1]

A typical dose is about 1,000 mcg a day

Choline can be made in the liver

Weeks 8-12: Peak Effect Window Weeks 8 through 12 represent the peak efficacy window based on the Phase 2 trial duration