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Observed outcomes include specific cellular and molecular endpoints such as: Enhanced fibroblast migration capacity Increased collagen and elastin deposition Modulation of pro-inflammatory and antioxidant mediators Altered transcriptional profiles related to tissue homeostasis, repair signaling, and stress response All reported observations derive exclusively from preclinical laboratory and animal studies and remain model-specific

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Moreover, differences in therapeutic outcomes and mechanisms among stem cells derived from various sourcessuch as bone marrow, umbilical cord, or adipose tissueneed to be systematically compared

BMJ Open Diabetes Res Care, 2019