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MSCs, for instance, can differentiate into osteoblasts, chondrocytes, and adipocytes through the activation of the Wnt/-catenin pathway and the TGF-/SMAD signaling axis

IGFBP-4 Lnc-IGFBP4-1 is a recently-described lncRNA located in the upstream region of the IGFBP4 gene

However, the biosimilar pathway for complex peptide medications is accelerating, and several manufacturers have signaled interest in developing competing versions once patents expire

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