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If you are losing more than 2 percent of body weight per week over more than two consecutive weeks, that is a hold signal too, because the deficit is likely too aggressive for lean mass preservation regardless of how motivated you feel

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Juli-Romero C, Palau-Mart C, Tejedor-Bosqued A

GLP-1: An Overview Glucagon-like peptide-1 (GLP-1) agonists act by stimulating insulin secretion in hyperglycemic states, suppressing glucagon secretion in hyperglycemic or euglycemic states, delaying gastric emptying, decreasing appetite, and reducing body weight