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Some users may report mild pain or discomfort at the injection site
Initial trials of semaglutide in pregnant rats showed an increase in pregnancy loss, birth defects and low birth weight 8
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Clinicians avoid prescribing GLP-1 agonists for individuals with a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2A (MEN 2A), or type 2B (MEN 2B) (51)(53)
Article Text Abstract Objectives Many people with type 2 diabetes experience clinical inertia, remaining in poor glycaemic control on oral glucose-lowering medications rather than intensifying treatment with a glucagon-like peptide-1 receptor agonist, despite an efficacious, orally administered option, oral semaglutide, being available
Several GLP-1 RAs were subsequently shown to reduce cardiovascular risk in patients with type 2 diabetes with or at high risk for atherosclerosis
