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The formation of a covalent link between a highly polar group, such as a glucose, sulfate, or the tripeptide glutathione, directly to a drug molecule or its phase I metabolite increases the hydrophilicity of the molecule and ultimate excretion in the urine or bile

Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a transcription factor and a central regulator of the bodys oxidative stress response 11,12 , so that activating Nrf2 holds promise as an effective therapeutic strategy in OA

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