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Figure 4 Alterations in the intracellular redox status are often associated with GSH depletion (Polonikov, 2020) and endogenous GSH deficiency, due either to decreased biosynthesis and/or increased consumption, is a marked contributor to the pathogenesis of numerous diseases via mechanisms including oxidative stress and inflammation

This activation promotes various downstream effects, including inflammation, proliferation, apoptosis, autophagy and other processes associated with many human pathologies such as diabetes, neurodegenerative and cardiovascular diseases (6972)

Heidari P, Entazari M, Ebrahimi A, Ahmadizadeh M, Vannozzi A, Palumbo F, et al

Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation

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