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One category of mediators are those that directly interfere with specific processes of immunity, for example a cysteine protease inhibitor that blocks MHC class II processing
We use experimentally determined forms for these allosteric interactions but sometimes the details of the kinetics are not known, forcing us to make reasonable educated guesses
While individually they have relatively benign safety profiles (when used appropriately), the interaction between them has not been thoroughly investigated in clinical settings
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Secukinumab and ustekinumab can cause headache and fatigue as well as allergic or injection-site reactions
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