To tighten barrier integrity and induce BBB properties, a cocktail of small molecules, cARLA, was applied to activate the cyclic AMP and Wnt/-catenin and inhibit the TGF- signaling pathways (Fig
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Clinical trials have tested the effects of GLP-1R agonists in patients with PD, AD, or diabetes-related memory impairment, showing significant improvement in these patients conditions (69)
2025: Novo Nordisk announced positive Phase 3 ESSENCE trial results for semaglutide in early Alzheimer's disease, reporting statistically significant slowing of cognitive and functional decline a breakthrough data package that could establish GLP-1 therapy as a neuroprotective agent and open an addressable market of 6.5 million Alzheimer's patients in the U.S
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