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Different routes affect tissue exposure, signaling, and outcomes
Its very important for those with a severe deficiency
Degraded or improperly synthesized GHK-Cu loses copper-binding geometry, converting what should be an antioxidant into a pro-oxidant by liberating catalytically active copper ions
Grx1 knockout mice show increased cellular protein S -glutathionylation 42 , and Grx2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells 43
Low glutathione levels are linked to chronic fatigue and low energy production
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