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Both are GLP-1 receptor agonists (tirzepatide is also a GIP agonist), and musculoskeletal effects relate to weight loss rate rather than drug class

Could improve exercise tolerance and endurance rather than subjective alertness. In insulin-resistant states, MOTS-C improves glucose utilization, which can reduce post-prandial crashes and chronic low-energy states

10.1016/j.biopha.2024.116424 59 XiongM.OuC.YuC.QiuJ.LuJ.FuC.et al (2023)

The lysates were incubated on ice for 30 min and centrifuged at 13,000 rpm for 15 min to remove debris

More research, especially from randomized controlled trials, is needed to determine whether vitamin D deficiency has adverse effects on cognition