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Sorafenib combined with ferroptosis inducerssuch as system Xc - inhibitors, GPX4 inhibitors, or iron-modulating agentsmay push ACSL4-enriched membranes beyond the oxidative threshold required for ferroptotic collapse

Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding [PMID: 29746824] Laboratory literature summary: Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD(+) supports substrate-level phosphorylation

Presented for research literature review only Davis PA et al