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For hair specifically, it helps your body metabolise amino acids (the building blocks of hair) which are crucial for strong, healthy strands
Gut stuff - nausea, constipation or diarrhea, bloating - mostly around dose increases, then it settles
What the margin difference looks like in practice: Community sources describe the room-temperature-stored punctured vial as more likely to reach the boundary of preservative efficacy within the 28-day window still technically within the documented period, but with less safety margin
General stone biology is useful background
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