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The anti-inflammatory Pharmacology of pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes
This protective action likely involves regulating antioxidant gene expression via Nrf2 activation, diminishing excessive ROS accumulation, and reducing oxidative damage markers (e.g., 3-NT and 4-HNE), as evidenced by J Fan et al.s study on STZ-induced diabetic mouse wounds treated with PCs ( The integration of nanomaterials and hydrogels with plant-derived active ingredients for wound healing has recently attracted significant interest among researchers