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The article discusses the pharmacokinetic challenges peptides face, such as low oral bioavailability due to poor membrane permeability and enzymatic degradation in the gastrointestinal tract
In senescent endothelial cells induced by OGD, treatment with FOXO4-DRI led to a significant increase in the expression of BAX and cleaved caspase-3 (c-Caspase-3), while the expression of BCL2 notably decreased
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