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Clinical studies show maximal reduction in ALT levels (a marker of liver damage) was achieved approximately 28-30 weeks after starting treatment 20
Regarding conversion, we can cite only a manufacturers claim saying that EAC is metabolized in the skin into pure ascorbic acid (and the ascorbic acid content of EAC is very high - 86,4% - compared to the usual 50-60% Vitamin C content of other derivatives)
Rizzo, P., Raffone, E., & Benedetto, V
Sustainability status of milk thistle Milk thistle is classified as least concern on the IUCN redlist due to stable populations in most of its native habitats and no major threats (17)
Additionally, some medications can affect glutathione levels
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