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Food and Drug Administration (FDA) senior compliance official also recently reiterated the agencys concern regarding certain advertising claims in this space
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VKTX would be a speculative position within a portfolio with additional de-risking data required following additional trials (slower titration for improved tolerability and TEAEs, increasing efficacy over longer duration, maintenance ability) to possibly allow for a more generous sizing/position
The weight begins to come off
Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death
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