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Temple JL
Metformin is contraindicated in patients with an eGFR 4 years) is associated with vitamin B12 deficiency in 10-30% of patients, likely due to interference with calcium-dependent B12 absorption in the terminal ileum
For diabetes management, the eligibility criteria included a diabetes diagnosis, a hemoglobin A1c (HbA1c) level of at least 7.0%, or current use of diabetes therapies
If lifestyle changes and approved medications don't control your symptoms within 68 weeks, your team may adjust your dose schedule, switch to oral tirzepatide, or explore other compounded GLP-1 options
2018, Harlan Teklad) or HFD (45% kcal fat, 35% kcal carbohydrate, 0.05% wt/wt cholesterol, D12451, Research Diets) with free access to food and water unless otherwise noted
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